Role of spironolactone in heart failure

Spironolactone is a potassium sparing diuretic that was originally developed in the early 1970s, as a competitive antagonist of aldosterone for the treatment of hyperaldosteronism, hypokalemia and edematous status as nephrotic syndrome. Recent studies on this drug has concentrated on its effect in patients with left sided H F as an aldosterone antagonist . It is postulated to work synergistically with ACEIs to provide more thorough blocking of the of the renin-angiotensin system
The effects of Spironolactone in patients with heart failure include:
1-On Renin-angiotensin -aldosterone system (RAAS):
RAAS is the complex mechanism by which the kidneys- control the cardiovascular system. In patients with heart failure the decreased renal flow is not due to low blood volume but to a heart pump that is not working efficiently.

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