الرئيسية / الفعاليات العلمية / ANTICANCER EFFECTS OF COMBINED PHOTOBIOMODULATION, CARBOPLATIN, CASSIA FISTULA SEEDS EXTRACT AND GOLD NANOPARTICLES (AUNPS) ON PROSTATE CANCER CELL LINE (PC3)

ANTICANCER EFFECTS OF COMBINED PHOTOBIOMODULATION, CARBOPLATIN, CASSIA FISTULA SEEDS EXTRACT AND GOLD NANOPARTICLES (AUNPS) ON PROSTATE CANCER CELL LINE (PC3)

ABSTRACT : Although, chemotherapy still the main mode for managing cancer but its usage is limited by resistance and
adverse effects which are depend on the dose. Other modes or techniques such as LASER irradiation, anti-cancer plant or nanometals
particles can be used to solve this problem. In this study, we use three different agents (carboplatin, cassia fistula seed
extract, and gold nanoparticles) where the cytotoxicity of them was investigated on prostate cancer (PC3) cell line. The PC3
cells were exposed to six doses for each of carboplatin, cassia fistula fruits extract, and gold nanoparticles. Then for each agent,
the dose that gave significant decrease in the viability percent was used in combination with a constant dose of He-Ne laser (635
nm). From the results, we found that the inhibition percent was increased by the combination therapy as compared to the monotherapy
for each agent. Also, the highest inhibition percent was observed in the combination of gold nanoparticles and 191 J/cm2
laser. In a conclusion, LAESR is an amazing technique to increase the cytotoxicity of the classical and non-classical methods
for treating cancer especially its use in combination with gold nano-particles in the photo-thermal technique.

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