الرئيسية / الفعاليات العلمية / مقالات / MSC.pharmaceuticsMalathHatif AL-mussawi …..Oral Thin Film as Drug Release

MSC.pharmaceuticsMalathHatif AL-mussawi …..Oral Thin Film as Drug Release

The thin films are a novel drug delivery systems, thin films have been recognized as alternate mean to conventional dosage forms. Generally, oral films can be stated as thin and flexible layers of polymer with or without using of plasticizer,as they are thin and flexible by their nature, therefore, it is more satisfactory to the patient.
Also the thin films are polymeric matrices that meet many necessities for being used efficiently as a drug release platform .Essentially, thin films are excellent candidates for targeting sensitive site that may not be possible with tablets or liquid formulations. Ideal thin films need to show desirable features for example quick dissolution rate or extended residence time at site of administration, appropriate drug loading capacity, and adequate manufacture stability. Also, they would be biodegradable, biocompatible and non-toxic. Significant efforts have been made to formulate polymeric thin films that are administered viabuccal, sublingual, ocular and skin routes. Among these routes, the use of oral films for delivering medication into sublingual or buccal mucosa has drawn immense interest in New Year’sto get fast onset of action, increased effectiveness and safety of the drugmay be useful for eradicating side effects of a drug and decreasing extensive metabolism produced by proteolytic enzymes and it is more stable, durable than other conventional dosage forms, and have advance dosing accuracy related to liquid preparations,not need water for swallowing, leave less or no residue in the oral cavity and have thin and elegant appearance,oral films administered to pediatric and geriatric patient population where they have difficulty in swallowing of larger oral dosage forms.
Structures of polymers of various grades have simplifiedthe adjustment of key features of thin films for instance drug release rate, mucoadhesive properties and mechanical strength , increase bioavailability of drugs especially for insoluble and lipophilic medicines due to its rapid disintegration and drug release property, and so enhanced patient compliance.Moreover, various inactive components can be involved such as sweeteners, plasticizers and colorants for beneficial aesthetic characteristics, in addition to saliva stimulating agent. The oral films presented indifferent sizes and shapes, are more appropriate when fast onset of action is required especially in treatment of abrupt conditions of allergic disease, asthma, coughing, or motionsickness.

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