problems in both male and female animals, including infertility even when they used in low concentrations . Vitamin E is present in fatty foods and, its lipophilic so it allows being stored within the fatty tissues. All the different homologues in varying proportions among the tocopherols, the alpha and gamma-tocopherols are present in the serum and in the erythrocytes. The function of vitamin E is the protects tissues from the oxidative stress. Vitamin E inhibits the production of reactive oxygen after the oxidation or formation of fats of free radical .Vitamin A is a group of lipophilic biomolecules which is important
to complete many vital biological function. Vitamin A, may play a role as a hormone-like growth factor for
epithelial tissue and many other cell in the human body . vitamin A is utilized therapeutically for treatment of many cases such as dermatological disturbances, immunodeficiency, and leukemia, and in reduction of toxicity by increasing glutathione-S transferase (GST) enzyme activity .The other important vitamin is vitamin D3 ,the pharmacological properties of vitamin D3 have congregate much attention, especially in the previous decades due to the delineation of its exact molecular pharmacodynamics. A number of analogs are being produced to extend the utility of this metabolite to a diversity of non-classic conditions.