Faculty of Pharmacy – University of Kufa Official Site – Faculty of Pharmacy
Researcher Names: Dr.Zubaida Falih Alzubaidi, Dr. Noaman Ibadi Mohammed, Dr. Muneer Khudhair
Research title: The relevance of rs6777038 and rs6444082 of igf2bp2 gene polymorphism and type 2 diabetes mellitus: a case control study
The research covered: The study involves 800 participants that divided to a healthy control group (400) and T2DM patients (400).
The research aimed at: We investigate IGF2BP2 gene polymorphisms (rs6777038 and rs6444082) association with T2DM of Iraqi sample
The research results showed: Logistic regression analysis testing for rs6777038 revealed that the genotype and allele frequency differ significantly (p=0.009) between T2DM and control group. In codominant model, TT genotype carriers had higher risks for diabetes than control also in the recessive model TT genotype significantly had higher risk for diabetes than control group. The other models of rs6777038 failed to reveal significant differences. The rs6777038 genotypes as codominant model showed significant differences with phenotypic characters of BMI, insulin and HOMA-IR. As well as, this SNP as dominant model showed significant differences with fasting insulin and HOMA-IR. However, rs6444082 genotypes only as dominant model reveal significant variation with HOMA-IR
Research conclusion: This study confirmed the variant rs6777038 of IGF2BP2 possibly associated with T2DM risks and some anthropometric parameters such as lower fasting insulin, HOMA-IR and BMI in Iraqi T2DM participants.
