University of Kufa, Faculty of pharmacy discussed the Master’s thesis titled “In Silico Study, Synthesis, and Preliminary Anti-Cancer Evaluation of New compounds Incorporating Thiazole Moiety As Carbonic Anhydrase Inhibitors.” by the student Israa Mahdi Naji.
The thesis aimed to design and chemically synthesize compounds as potential cancer treatments, overcoming the resistance exhibited by cancer cells. The study found that these compounds could potentially inhibit the biological activities of cancer cells by targeting the carbonic anhydrase enzyme. The researcher recommended further testing on these compounds.
In summary, six new compounds containing sulfonamide groups and thiazole ring derivatives were designed and synthesized as carbonic anhydrase inhibitors for cancer treatment. Molecular docking studies were conducted using the MOE program to select the most suitable compounds based on their S scores. Subsequently, an MTT assay was performed to evaluate the anticancer activity of the target compounds. The synthesized compounds demonstrated inhibition of cancer cell viability. These results shed light on the potential of these compounds as candidates for future research in cancer therapy.